Yang Hai

Assistant Professor

Contact Phone

(805) 893-8085

Office Location

CHEM 1126B
CHEM 1132 (lab)

Specialization

Education

Ph.D. in Chemistry at the University of Pennsylvania (2011-2016)

Bio

Dr. Hai received his B.S. in Chemistry from Peking University in 2011. He then pursued a Ph.D. in Chemistry at the University of Pennsylvania (2011-2016) under the guidance of Prof. David W. Christianson. At UPenn, he focused on studying the structure and function relationship of metallohydrolases primarily using protein X-ray crystallography; and developed a keen interest in enzyme mechanism, catalysis and inhibition. He then pursued postdoctoral studies (2016-2020) in the group of Prof. Yi Tang at UCLA to study fungal natural product biosynthesis, where he discovered new enzymes and metabolic pathways through genome mining. In 2018, Dr. Hai spent a summer at the Marine Biological Laboratory at Woods Hole to study microbiology, where he was intrigued by the microbial diversity in nature.

Research

http://hai.chem.ucsb.edu/

In this postgenomic era, the exponentially growing number of protein and DNA sequences provides tremendous opportunities to discover novel enzymes carrying out unusual biochemical transformations; metabolites/natural products with new biological activities, and previously unknown metabolic/biological pathways. The Hai research group will (1) integrate both chemical and biological approaches to uncover new enzyme functions and expand the toolboxes of enzymes in biocatalysis; (2) focus on the structure-function relationship of emerging enzymes implicated in human diseases and agriculture. In addition to our expertise in biochemistry, we will also collaborate with materials scientists and engineers on campus to develop biocatalytic and synthetic biological approaches for synthesizing new biopolymers and other biomaterials.

Publications

Liu S, Gao J, Zou Y, Hai Y.* (2024) Enzymatic synthesis of unprotected a,b-diamino acids via direct asymmetric Mannich reaction. J. Am. Chem. Soc. 146, 29, 20263–20269.

Liu S, Yeh C, Reavill C, Jones B, Zou Y, Hai Y.* (2024) Molecular and structural basis for Cγ-C bond formation by PLP-dependent enzyme Fub7. Angew. Chem. Int. Ed. 63, e202317161

Liu S, Hai Y.* (2023) Chemoenzymatic approaches to izidine alkaloids: an efficient total synthesis of (+)-absouline and laburnamine. ACS Catal. 13, 15725-15729.

Liu S, Lara D, Hai Y.* (2023) Mining the noncanonical terpenome. Nat. Chem. Biol. 19, 1440-1442.

Gao J, Zhou C, Hai Y.* (2023) Stereoselective Biocatalytic α-Deuteration of L-Amino Acids by a Pyridoxal 5’-Phosphate-Dependent Mannich Cyclase. ChemBioChem e202300561.

Gao J, Liu S, Zhou C, Lara D, Zou Y,* Hai Y.* (2023) A pyridoxal 5’-phosphate-dependent Mannich cyclase. Nat. Catal. 6, 476-486.