Research:
I study the effects of cosolvents on proteins. We are interested in understanding the effects of cellular components on the conformational stability and aggregation propensities of intrisically disordered proteins (IDPs). I have particular interest in the behavior of the IDP tau protein, associated with the pathology of Alzheimer's disease.
Publications:
Laos, V.; Bishop, D., Ganguly; Schonfeld, G.; Trapp, B.; Lazar Cantrell, K.; Buratto, S.; Shea, J.-E.; Bowers, M. J. Am. Chem. Soc. 2021, 143 (9), 3494-3502
Terminal capping of an amyloidogenic Tau fragment modulates its fibrillation propensity
Arya, S.; Ganguly, P.; Arsiccio, A.; Claud, S. L.; Trapp, B.; Schonfeld, G. E.; Liu, X.; Lazar Cantrell, K. L.; Shea, J.-E.; Bowers, M. T. J. Phys. Chem. B 2020, 124 (40), 8772-8783.