| People
- Faculty
- Professor:
Daniel Little |
| Field(s): |
Organic Chemistry |
 |
| Email: |
little@chem.ucsb.edu |
| Phone: |
(805)
893-
3693 |
Fax:
(805)
893-
4120 |
| Office: |
3649C/D PSB North |
 |
Selected
Publications |
|
Go
to Research Group website |
| Bio: |
Dr. Little received his Ph.D. in 1974 from the University of Wisconsin, and was a postdoctoral fellow at Yale before joining the faculty at UC Santa Barbara in 1975. He is the recipient of an A. P. Sloan Foundation Fellowship and the H. J. Plous Award at UCSB. Dr. Little has been a visiting professor at the University of British Columbia, served on the Medicinal Chemistry Study Section of the NIH. |
|
Current
Research
Overview: Our research focuses upon the development, use, and understanding of new reactions and new strategies for the synthesis of bioactive materials. Current target structures include the antitumor agents aphidicolin, ophiobolin and taxotere, as well as analogs of the phorbol esters. The construction of molecules of this complexity requires the use of efficient and selective reactions, and this is certainly true of the chemistry we seek to develop. Our approaches allow exploration of the chemistry of a variety of interesting and reactive intermediates, including diradicals and species that are most readily generated using redox chemistry. Of particular appeal is the fact that, being new reactions, each of the key transformations can be studied at a fundamental, mechanistic level in order to understand and most effectively use them to synthesize the complex structures. Implementation of this chemistry requires that one learn how to handle a wide variety of reagents and conduct many different kinds of reactions. The mechanistic aspect of the work allows one to develop skills that encompass a wide range of spectroscopic and calculational tools.
|
| Selected
Research Publications |
|
Young Sam Park, Selina Wang, Tean Tantillo, R. Daniel Little, A Highly Selective Rearrangement of a Housane-derived Cation Radical; an Electrochemically Mediated Transformation, J. Org. Chem. 2007, in press.
|
|
James A. Miranda and R. Daniel Little, Investigation of vinylcyclopropane monoradical cyclization -fragmentation as a possible route towards eight-membered rings, Heterocycles (issue to honor Professor Steven Weinreb), 2006 , 70, 169-175.
|
|
Joohee Hong, Richard Yee, and R. Daniel Little, Progress toward the synthesis of the bicyclo(6.3.0) framework using TMM diyls, Arkivoc (issue in honor of the 65th birthday of Professor Atta-ur-Rahman, available on-line at: www.arkat-usa.org, in volume 2007, Part (vii), page number 233.
|
|
Wade A. Russu and R. Daniel Little, Bis(2,2,2-trichl oroethyl) Azodicarboxylate, Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS), in press, 2006, Wiley.
|
|
Gisele A. Nishiguchi, John Graham, A. Bouraoui, R.S. Jacobs, R. Daniel Little, 7,11-Epi-Thyrsiferol: Completion of its Synthesis, Evaluation of its Antimitotic Properties, and the Further Development of an SAR Model, J. Org. Chem. 2006, 71(16), 5936-5941.
|
|
Richard Yee, Jennifer Mallory, J. D. Parrish, Georgia Law Carroll, R. Daniel Little, The Influence of Electrogenerated Sm(II), Electrogenerated Yb(II), and Magnesium Ions Produced at a Sacrificial Anode, Upon the Diastereoselectivity of Electroreductive Cyclization Reactions, Electroanalytical Chemistry (Special issue in honor of Peter Zuman), 2006, 593, 69-73.
|
|
Daniel Little and Gisele A. Nishiguchi, Synthetic Efforts Toward, and Biological Activity of, Thyrsiferol and Structurally-Related Analogues, Studies in Natural Product Chemistry (Bioactive Natural Products), Ed.: Atta-ur-Rahman; Elsevier: Amsterdam, Netherlands, in press 2006.
|
|
|