| People
- Faculty
- Professor:
Bruce H. Lipshutz |
| Field(s): |
Organic Chemistry |
 |
| Email: |
lipshutz@chem.ucsb.edu |
| Phone: |
(805)
893-
2521 |
Fax:
(805)
893-
8265 |
| Office: |
2221 Chem |
 |
Selected
Publications |
|
Go
to Research Group website |
| Bio: |
Dr. Lipshutz arrived at UC Santa Barbara in 1979 after completing a two-year American Cancer Society postdoctoral fellowship at Harvard University. He received his Ph.D. from Yale University. Dr. Lipshutz is the recipient of an Alfred P. Sloan Fellowship, a Camille and Henry Dreyfus Teacher-Scholar Award, UCSB's Plous Memorial Teaching Award, an ACS Cope Scholar Award, and the UCSB Foundation Distinguished Faculty Teaching Award. |
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Current
Research
Research in our group covers several areas within the realm of synthetic organic chemistry. One of the overriding philosophies in our approach to the development of new reagents and methodologies is that they be of a practical nature; that they constitute contributions that other synthetic chemists will find useful. Some of the areas in which we currently have active programs include:
Organometallic Chemistry
Several new organometallic reagents and methods are under intense development, including (1) nonracemic ligated forms of CuH, being applied to asymmetric hydrosilylations and asymmetric 1,4-reductions; (2) the heterogeneous catalyst nickel-on-charcoal (Ni/C), which is very effective as an inexpensive, recyclable (i.e., "green") reagent alternative to palladium-catalyzed C-C and C-heteroatom bond formations; (3) further development of nickel-on-graphite (Ni/Cg) as a heterogeneous catalyst for cross-coupling reactions; (4) applications of copper-in-charcoal (Cu/C) in catalysis (5) development of novel mixed-metal catalysts; (6) design and synthesis of new ligands of the binaphthyl type. Applications to natural products (e.g., the nutraceutical coenzyme Q10) are ongoing.
Naturally Occurring, Nonracemic Biaryls
A number of unique routes to the key subsection of vancomycin aglycon are being pursued which are aimed at providing the crucial biaryl directly and in stereochemically pure form. Related approaches are being developed for syntheses of korupensamines, michellamines, and several other biaryls that possess axial chirality.
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| Selected
Research Publications |
An
updated list of selected
research publications is available on the group webpage.
|
| Professor
Lipshutz has created animations of selected mechanisms of
organic reactions very useful for teaching introductory
inorganic chemistry. They are
available on a CD ROM in both Windows
and Macintosh
versions. |
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