| People
- Faculty
- Professor:
Song-I Han |
| Field(s): |
Physical Chemistry, Biophysics |
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| Email: |
songi@chem.ucsb.edu |
| Phone: |
(805)
893-4858 |
Fax:
(805)
893-4120 |
| Office: |
3223 Chem |
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Selected
Publications |
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Go
to Research Group website |
| Bio: |
Dr. Han received her Doctoral Degree in Natural Sciences (Dr.rer.nat) from Aachen University of Technology, Germany, in 2001. She was awarded with the first Raymond Andrew Prize of the Ampere Society and Borchers Plakette of the Aachen University of Technology for an outstanding PhD thesis in magnetic resonance. She pursued her postdoctoral studies at the Max-Planck Institute for Polymer Research, Mainz, Germany and the University of California, Berkeley. At UC Berkeley, she was under the sponsorship of the Feodor Lynen Fellowship of the Alexander von Humboldt Foundation. Dr. Han joined the faculty at UCSB in 2004. She is a recipient of the Camille and Henry Dreyfus New Faculty Award, the NSF Faculty Early Career Development Award and a co-recipient of the W.M. Keck Award for Science and Technology. |
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Research Objective
Compared to traditional Nuclear Magnetic Resonance (NMR) where the signal originates from thermal polarization, Dynamic Nuclear Polarization (DNP) enhanced NMR offers a sensitivity gain by up to 4 orders of magnitude. The DNP principle uses highly populated unpaired electron spins, which electron spin resonance (ESR) signal is effectively translated into NMR signal, so that the nucleus of choice (e.g. 1H, 13C, 15N, 31P) in the molecule or material of interest is polarized and prepared for NMR detection. This can bring the detection limit of NMR from the traditional millimolar concentration down to the nanomolar concentration range, and/or allows experiments to be performed with no signal averaging, transforming NMR into a fast and dynamic spectroscopic method. Another approach that the Han group is developing is to employ DNP to provide NMR with unique contrast through polarization transfer from spin labels to the local environment, allowing for the study of large molecular assemblies such as vesicles or lipid bilayer embedded membrane proteins that are difficult to approach by conventional NMR spectroscopy. For the first time, the use of DNP for the "real-time" monitoring of protein aggregation through the site-specific detection of water exclusion as hydrophobic fibrous materials form and enzyme-catalyzed reaction turnover in live bacteria become viable. The Han lab's research objective is the development of a DNP-NMR (0.3-7 Tesla) and pulsed electron spin resonance (9 Tesla) instrument and technique for the application in biochemistry and materials research. The principle of DNP is known, but the approach of its usage is innovative and its application scope new.
Current
and Future Research
- Development of a cw 0.35 T and cw 7 T DNP-NMR apparatus
- Development of a pulsed 240 GHz EPR apparatus with nanosecond temporal resolution
- Monitoring of protein folding and protein aggregation
- Reaction monitoring of enzyme-catalyzed reactions
- Studying the dynamics and function of bilayer-embedded proteorhodopsin protein
- Hyperpolarized water as a unique contrast agent for magnetic resonance imaging
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| Selected
Research Publications |
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"Portable X-Band System for Solution State Dynamic Nuclear Polarization", B.D. Armstrong, M.D. Lingwood, E.R. McCarney, E.R. Brown, P. Blümler, S. Han, J. Magn. Reson. (2008), doi: 10.1016/j.jmr.2008.01.004.
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"Spin-labeled gel for the production of radical-free dynamic nuclear polarization enhanced molecules for NMR spectroscopy and imaging", E.R. McCarney, S. Han, J. Magn. Reson. 190 (2008), 307-315.
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"Dynamic Nuclear Polarization Enhanced Magnetic Resonance Analysis at 9.8 GHz using Amplified 1H Water Signal", S. Han and E. R. McCarney, in S. Codd, J. Seymour (Eds.) "Magnetic Resonance Microscopy", Wiley-VCH, Weinheim, Germany, 2008.
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"A New Model for Overhauser Enhanced Nuclear Magnetic Resonance Using Nitroxide Radicals", B. D. Armstrong, S. Han, J. Chem. Phys. 127 (9) (2007).
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"Hyperpolarized water as an authentic magnetic resonance imaging contrast agent", E. R. McCarney, B. L. Armstrong, M. D. Lingwood, S. Han, Proc. Nat. Acad. Sci. USA. 104 (6) (2007) 1754-1759.
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"Para-hydrogen induced polarization in heterogeneous hydrogenation reactions", I.V. Koptyug, K.V. Kovtunov, S.R. Burt, M.S. Anwar, C. Hilty, S. Han, A. Pines, R.Z. Sagdeev, J. Am. Chem. Soc. 129 (17) (2007) 5580-5586
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S. Stapf, S. Han, "Nuclear Magnetic Resonance Imaging", Ullmann Encyclopedia Article, Wiley-VCH, Germany, in press, 2007.
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S. Han, S. Stapf, "Fluid flow and trans-membrane exchange in a hemodialyzer module", in S. Stapf, S. Han (Eds.) "NMR Imaging in Chemical Engineering"d Wiley-VCH, Weinheim, Germany, (2006).
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S. Han, J. Granwehr, C. Hilty, "Broadening the application range of NMR and MRI by remote detection", in S. Stapf and S. Han (Eds) NMR Imaging in Chemical Engineering, Wiley-VCH, Weinheim, Germany (2006).
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NMR Imaging in Chemical Engineering, S. Stapf and S. Han (Eds), Wiley-VCH, Weinheim, Germany (2006).
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Click
here for a more complete list of research publications
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