SELECTED PUBLICATIONS
(updated periodically)

For online access to the publications, please access SciFinder Scholar, the
publishers, or see the library’s hard copy.

Wei Zhong and R. Daniel Little, Exploration and Determination of the Redox Properties of the Pseudopterosin Class of Marine Natural Products, Tetrahedron (Symposium in Print: Electron transfer reagents in organic synthesis), R. A. Flowers, II and D. J. Procter, editors, 2009/10, doi:10.1016/j.tet.2009.09.021

Wei Zhong and R. Daniel Little, Intramolecular Diyl Trapping Reactions en Route to the Bicyclo [3.2.1] Framework; an Approach to Aphidicolin, Tetrahedron Letters 2009, 50, 4994-4997 doi:10.1016/j.tetlet.2009.06.083

Young Sam Park and R. Daniel Little, Rearrangements of electrochemically generated cation radicals: The quest for regiochemical control and an application to total synthesis, Electrochimica Acta, 2009, 54, 5077-5082.  doi:10.1016/j.electacta.2009.01.020

Virginia M. Tanis, Claudia Moya, R. S. Jacobs, R. Daniel Little, Synthesis and evaluation of the bioactivity of simplified analogs of the seco-pseudopterosins; progress toward determining a pharmacophore, Tetrahedron, 2008, 64 (47), 10649-10663     http://dx.doi.org/10.1016/j.tet.2008.09.025

Wei Zhong, Claudia Moya, R. S. Jacobs, R. Daniel Little, Synthesis and an evaluation of the bioactivity of the C-glycoside of pseudopterosin A (PsA) methyl ether, J. Org. Chem. (Featured Article), 2008, 73, 7011-7016        http://dx.doi.org/10.1021/jo801432t

Young Sam Park and R. Daniel Little, Redox electron transfer reactions: electrochemically mediated rearrangement, mechanism, and a total synthesis of daucene, J. Org. Chem. 2008, 73(17), 6807-6815 Web Release Date: 30-Jul-2008; DOI: 10.1021/jo801199s

Christophe Hoarau, Daniel Day, Claudia Moya, Guang Wu, Abdul Hackim, Robert S. Jacobs, R. Daniel Little, iso-PsE, a new pseudopterosin, Tetrahedron Lett. 2008, 49(31), 4604-4606; http://dx.doi.org/10.1016/j.tetlet.2008.05.106

R. Daniel Little and Gisele A. Nishiguchi, Synthetic Efforts Toward, and Biological Activity of, Thyrsiferol and Structurally-Related Analogues, Studies in Natural Product Chemistry (Bioactive Natural Products), Volume 35, Ed.: Atta-ur-Rahman; Elsevier: Amsterdam, Netherlands, 2008. pdf

Joohee Hong, Richard Yee, and R. Daniel Little, Progress toward the synthesis of the bicyclo(6.3.0) framework using TMM diyls, Arkivoc (issue in honor of the 65th birthday of Professor Atta-ur-Rahman, available on-line at: www.arkat-usa.org, in volume 2007, Part (vii), page number 233.  pdf

Young Sam Park, Selina Wang, Tean Tantillo, R. Daniel Little, A Highly Selective Rearrangement of a Housane-derived Cation Radical; an Electrochemically Mediated Transformation, J. Org. Chem. 2007, 72(12), 4351-4357  PDF

James A. Miranda and R. Daniel Little, Investigation of vinylcyclopropane monoradical cyclization -fragmentation as a possible route towards eight-membered rings, Heterocycles (issue to honor Professor Steven Weinreb), 2006, 70, 169-175   PDF

Wade A. Russu and R. Daniel Little, Bis(2,2,2-trichloroethyl) Azodicarboxylate, Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS), in press, 2006, Wiley.  PDF

Gisele A. Nishiguchi, John Graham, A. Bouraoui, R.S. Jacobs, R. Daniel Little, 7,11-Epi-Thyrsiferol: Completion of its Synthesis, Evaluation of its Antimitotic Properties, and the Further Development of an SAR Model, J. Org. Chem. 2006, 71(16), 5936-5941.  PDF

Richard Yee, Jennifer Mallory, J. D. Parrish, Georgia Law Carroll, R. Daniel Little, The Influence of Electrogenerated Sm(II), Electrogenerated Yb(II), and Magnesium Ions Produced at a Sacrificial Anode, Upon the Diastereoselectivity of Electroreductive Cyclization Reactions, Electroanalytical Chemistry (Special issue in honor of Peter Zuman), 2006, 593, 69-73. PDF

James Miranda, Carolyn Wade and R. Daniel Little, Indirect Electroreductive Cyclization and Electrohydrocyclization Using Catalytic Reduced Nickel(II) Salen, J. Org. Chem. 2005, 70(20), 8017-8026. PDF

Gisele A. Nishiguchi and R. Daniel Little, From C-Glycosides to Pyranopyrans: An Approach to Thyrsiferol using Titanium(III) Promoted Redox Couplings, J. Org. Chem. 2005, 70(13), 5249-5256. PDF

James B. Gerken (UCSB), Selina C. Wang (UCD), Alejandro B. Preciado (UCSB), Young Sam Park (UCSB), Gisele Nishiguchi (UCSB), Dean J. Tantillo (UCD), and R. Daniel Little (UCSB), Remote Substituent Effects upon the Rearrangements of Housane Cation Radicals. J. Org. Chem. 2005, 70(12), 4598-4608. PDF

Frontana-Uribea, Bernardo A.; Little, R. Daniel. The positive effect of oxygenated solvents for the synthetic use of electroregenerated ytterbium(II). Electrochimica Acta 2005, 50(6), 1383-1390. PDF

Maiti, Arup; Gerken, James B.; Masjedizadeh, Mohammad R.; Mimieux, Yvette S.; Little, R. Daniel. From Dimerization, to Cycloaddition, to Atom Transfer-Cyclization (ATC). The Further Chemistry of TMM Diradicals. J. Org. Chem., 2004, 69(25), 8574-8582. PDF

Carter-Franklin, Jayme N.; Parrish, Jon D.; Tschirret-Guth, Richard A.; Little, R. Daniel; Butler, Alison. Vanadium Haloperoxidase-Catalyzed Bromination and Cyclization of Terpenes. J. Am. Chem. Soc. 2003, 125(13), 3688-3689.  PDF

Carroll, Georgia Law; Harrison, Roy; Gerken, James B.; Little, R. Daniel. Coping with substituent effects in divinylcyclopropyl diazene rearrangements. Tetrahedron Lett. 2003, 44(10), 2109-2112.  PDF

Little, R. Daniel; Moeller, Kevin D. Organic electrochemistry as a tool for synthesis. Umpolung reactions, reactive intermediates, and the design of new synthetic methods. Electrochemical Society Interface 2002, 11(4), 36-42.  PDF

Russu, Wade A.; Villalon, Veronica P.; Wang, Vivian R.; Miranda, James A.; Little, R. Daniel. [3+2] Versus [4+3] cycloaddition of conjugated dienes to TMM diradicals. Tetrahedron Lett. 2002, 43(47), 8459-8461.  PDF

Parrish, J. D.; Little, R. Daniel. Preparation of a-C-Glycosides from Glycals. Org. Lett. 2002, 4(9), 1439-1442.  PDF

Parrish, J. D.; Little, R. D. Electrochemical generation of low-valent lanthanides. Tetrahedron Lett. 2001, 42(44), 7767-7770.  PDF

Carroll, Georgia Law; Little, R. Daniel. Inter- and Intramolecular Reductive Coupling Reactions: An Approach to the Phorbol Skeleton. Org. Lett. 2000, 2(18), 2873-2876.  PDF

Carroll, Georgia Law; Allan, Amy Kim; Schwaebe, Michael K.; Little, R. Daniel. Atom Transfer Reactions of TMM Diyls Directed toward the Synthesis of Rudmollin. Org. Lett. 2000, 2(16), 2531-2534.  PDF

We can be reached at (805)893-3953 or little@chem.ucsb.edu