Design, Synthesis, and Application of Adaptive Organic Molecules

We are exploiting unique organic reactions to develop small organic molecules (mw 200 - 1500) with the ability to rapidly change their chemical and physical properties without chemical reagents. Using synthetic organic chemistry and reaction development, along with inspiration from natural products and physical organic chemistry, we are synthesizing molecular entities that can morph themselves into 10^5 different constitutional isomers, thus modulating their chemical and physical properties. The ability of these molecules to dramatically adjust their shape and chemistry will be exploited throughout the spectrum of contemporary chemical and biological problem