Single nanoparticles and enzymes catalysis

I. Using new electrochemical techniques it is now possible to characterize individual nanoparticles in situ. It is also possible to replace the conventional nanofabrication techniques and use nanoparticles as the nanoelectrodes and investigate the particle catalytic activity at the single entity level.

Our lab will focus on investigating various types of nanoparticles (including semiconducting NP) in order to learn about their physical properties. On top of that, our goal is to develop low noise electronic systems in order to resolve in situ small nanoparticles and perhaps even nano-clusters and enzymes.

II. Enzymes are typically natural efficient catalysts. The macroscopic behavior of enzymes has been attracted the scientific community for over a century.

However, a clear knowledge on the catalytic activity at a single enzyme level is still missing. Because of the flexibility and the dynamical structure of enzymes, each enzyme may have its own catalytic rate and this catalytic rate may not be constant over time (static and dynamic disorder).

We seek to investigate the mechanism of single enzyme catalysis by state of the art electrochemical techniques, which includes low noise electronic systems that is sufficient enough to enable detecting electronic signal above the noise level, arising from a single enzyme.