Research

The Reich lab investigates the complexity of cellular machinery on two fronts: to elucidate role of DNA binding enzymes in the epigenetic disposition of gene expression and suppression; and the design of nanoparticle tools to harness cellular processes for therapuetic and investigative purposes. Emphasis is placed on understanding the complexity of how DNA binding enzymes travel extensive distances along genomic DNA and perform specific activities at incredible speeds. Furthermore, design of novel nanoparticle architectures are being engineered to utilize cellular machines to elicit a specific effect in a time and space dependent manner. 

The Latest:

Enzymology

Caulobacter crescentus Cell Cycle-Regulated DNA Methyltransferase Uses a Novel Mechanism for Substrate Recognition

 

Nanoparticle Drug Delivery

Modularized Gold Nanocarriers for TAT-Mediated Delivery of siRNA

Affinity-Based Assembly of Peptides on Plasmonic Nanoparticles Delivered Intracellularly with Light Activated Control