| People
- Faculty
- Professor:
Michael T. Bowers |
| Field(s): |
Physical Chemistry/Biochemistry/Materials |
 |
| Email: |
bowers@chem.ucsb.edu |
| Phone: |
(805)
893-2893 |
Fax:
(805)
893-4120 |
| Office: |
4249 Chem |
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Selected
Publications |
|
Go
to Research Group website |
| Bio: |
Dr. Bowers obtained his B.S. from Gonzaga University and
his Ph.D. in 1966 from the University of Illinois. After
two years at the Jet Propulsion Laboratory he joined the
UC Santa Barbara faculty in 1968. His Awards include:
the Nobel Laureate Signature Award of the American Chemical
Society (1988), the Field and Franklin Award of the American
Chemical Society (1996), the Thomson Gold Medal of International
Mass Spectrometry Society (1997), a Guggenheim Fellowship
(1995), and UCSB Faculty Research Lecturer (1994).
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Current
Research
Our research is centered on determination of the structure and/or
reaction dynamics and reaction mechanism of a number of exotic
species in the gas phase. These studies all utilize state-of-the-art
ion beam technologies and methodologies, most of which were
developed in our lab. The work is a blend of experiment and
theory. We bring a chemical physics outlook to problems of chemical
and biological interest.
At present, we are involved in two broad areas: nanoclusters/materials
and conformations, energeitcs and hydration of macromolecular
systems. In the nanocluster/materials area, we are looking at
size-selected metal clusters, their binding energies to catalytically
important ligands and the connection to the same chemistry on
clean semiconducter surfaces. The surface work is done in collaboration
with Profs. Buratto, McFarland, Metiu and Moscovitz. Other projects
include development of conducting organic films for use as LED's
and other electronic devices (in collaboration with the Buratto
and Bazan groups) and the hydration/dissolution energetics and
mechanism of small sea salt clusters.
We are interested in macromolecular systems of both industrial
and biological importance. Industrial systems include primary
and secondary structural/conformational mapping of both pure
and copolymer systems. Of particular interest are polyhedral
oligomeric silsesquioxanes (POSS), silicon/oxygen cages that
greatly enhance polymer properties when attached.
Biopolymer work has focused on the importance of conformational
analysis, salt bridge formation and hydration of both peptides
and oligonucleotides. This work continues. New projects are
aimed at misfolding/aggregation phenomena that underlie many
diseases, including Alzheimer's and various transmissible spongiform
encephalopathies (TSE). Both experimental and theoretical approaches
are being pursued.
Many more details and a publication list can be found on the
group web site.
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| Selected
Research Publications |
| An Investigation of the Mobility Separation of Some Peptide and Protein Ions Using a New Hybrid Quadrupole/Travelling Wave IMS/oa-ToF Instrument Steven D. Pringle, Kevin Giles, Jason L. Wildgoose, Jonathan P. Williams, Susan E. Slade, Konstantinos Thalassinos, Robert H. Bateman, Michael T. Bowers, and James H. Scrivens Int. J. Mass Spectrom. 2007, 261, 1-12. |
| Stabilization and Structure of Telomeric and c-myc Region Intramolecular G-Quadruplexes: The Role of Central Cations and Small Planar Ligands Valerie Gabelica, Erin Shammel Baker, Marie-Paule Teulade-Fichou, Edwin De Pauw, and Michael T. Bowers J. Am. Chem. Soc. 2007, 129, 895-904. |
| Intermolecular Interactions in Biomolecular Systems Examined by Mass Spectrometry Thomas Wyttenbach and Michael T. Bowers Annu. Rev. Phys. Chem. 2007, 58, 511-533. |
| Hydration of Mononucleotides Dengfeng Liu, Thomas Wyttenbach, and Michael T. Bowers J. Am. Chem. Soc. 2006, 128, 15155-15163. |
| Elucidating Amyloid \u03b2-Protein Folding and Assembly: A Multidisciplinary Approach David B. Teplow, Noel D. Lazo, Gal Bitan, Summer Bernstein, Thomas Wyttenbach, Michael T. Bowers, Andrij Baumketner, Joan-Emma Shea, Brigita Urbanc, Luis Cruz, Jose Borreguero, and H. Eugene Stanley Acc. Chem. Res. 2006, 39, 635-645. |
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