Research Group Website: http://www.chem.ucsb.edu/hangroup/
Dr. Han received her Doctoral Degree in Natural Sciences (Dr.rer.nat) from Aachen University of Technology (RWTH), Germany, in 2001. She pursued her postdoctoral studies at the Max-Planck Institute for Polymer Research, Mainz, Germany sponsored by the Max-Planck Fellowship and the University of California Berkeley sponsored by the Feodor Lynen Fellowship of the Alexander von Humboldt Foundation. Dr. Han joined the faculty at UCSB in 2004, received tenure in 2010 and was promoted to full professor in 2012.
My group’s research pushes the frontiers of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy for the study of materials, macromolecular complexes and biological interactions. The particular emphasis is on the interrogation of interfaces and local structures through locally amplified NMR spectroscopy, of materials and biological systems. The study of local features at the nanometer and sub nanometer scale is achieved through the use of strategic or intrinsic electron spin probes and by employing orders of magnitudes of signal enhancements, achieved through polarization transfer from the electron spin probes to the surrounding nuclear spins, which process is termed dynamic nuclear polarization (DNP). Our approach is to take advantage of the existing power and plethora of state of the art magnetic resonance tools, in particular the detailed structure elucidating capabilities of modern NMR spectroscopy, as well as cw and pulsed EPR spectroscopy at low and high magnetic fields for measuring long range distances (2-8 nm) and macromolecular interactions. My group has been pursuing a broad research agenda, beginning from the development of unique instrumentation and new experimental methods, to the development of new applications for elucidating materials microstructure and biological interfaces.
Publications list: (2012-2013 only)
J.H. Ortony, S.H. Choi, J.M. Spruell, J.N. Hunt, N.A. Lynd, D.V. Krogstad, V.S. Urban, C.J. Hawker, E.J. Kramer, S. Han, Fluidity and Water in Nanoscale Domains Define Coacervate Hydrogels, Chemical Sciences (2013) under review.
C.Y. Cheng, J. Varkey, M.R. Ambroso, R. Langen, S. Han, Hydration Dynamics as an Intrinsic Ruler for Refining Protein Structure at Lipid Membrane Interfaces, Proc. Natl. Acad. Sci. (2013) in press.
T. Kaufmann, T.J. Keller, J.M. Franck, R.P. Barnes, S.J. Glaser, J.M. Martinis, S. Han, DAC-board based X-band EPR Spectrometer with Arbitrary Waveform Control, J. Magn. Reson. 235 (2013) 95-108
J. M. Franck, A. Pavlova, J.A. Scott, S. Han, Quantitative cw Overhauser Dynamic Nuclear Polarization for the Analysis of Local Water Dynamics, Prog. Nucl. Magn. Reson., (2013) in press.
S.A. Walker, D.T. Edwards, T. Siaw, B.D. Armstrong, S. Han, Temperature Dependence of High Field 13C Dynamic Nuclear Polarization Processes below 35 Kelvin, Phys. Chem. Chem. Phys. 15 (36) (2013) 15106-15120
D.T. Edwards, Z. Ma, T.J. Meade, D. Goldfarb, S. Han, M.S. Sherwin, Extending the Distance Range Accessed with Continuous Wave EPR with Gd3+ Spin Probes at High Magnetic Fields, Phys. Chem. Chem. Phys., 15 (2013) 11313-11326
J.M. Franck, R. Kausik, S. Han, Overhauser Dynamic Nuclear Polarization-Enhanced NMR Relaxometry, Microporous and Mesoporous Materials, 178 (2013) 113-118.
J.H. Ortony, D.S. Hwang, J.M. Franck, J.H. Waite, S. Han, Asymmetric Collapse in Biomimetic Complex Coacervates Revealed by Local Polymer and Water Dynamics, Biomacromolecules, 14(5) (2013) 1395-1402.
- D.T. Edwards, Y. Zhang, S.J. Glaser, S. Han, M.S. Sherwin, Phase Cycling with a 240 GHz Free Electron Laser-powered Electron Paramagnetic Resonance Spectrometer, Phys. Chem. Chem. Phys., 15 (2013) 5707-5719
- J.M Franck, J.A. Scott, S. Han, Nonlinear Scaling of Surface Water Diffusion with Bulk Water Viscosity of Crowded Solutions, J. Am. Chem. Soc., 135(11) (2013) 4175-4178
- C.Y. Cheng and S. Han, Methods in Solids and Solutions to Explore Membrane Proteins and Membrane Systems, Annu. Rev. Phys. Chem., (2013) 64:507–32
- S. Hussein, J. M. Franck, S. Han, Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics, Angew. Chem. Int. Ed., 52(7) (2013) 1953-1958
- K. M. Stone, J. Voska, M. Kinnebrew, A. Pavlova, M. J. N. Junk, S. Han, Structural Insight into Proteorhodopsin Oligomers, Biophys. J., 104:2 (2013) 472-481
- C.Y. Cheng, J.G.M.O. Goor, S. Han, Quantitative Analysis of Molecular Transport across Liposomal Bilayer by J-mediated 13C Dynamic Nuclear Polarization, Anal. Chem., 84(21) (2012) 8936-3940
- C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: The Role of Hydration Dynamics Revealed by Dynamic Nuclear Polarization, Biomacromolecules, 13(9) (2012) 2624-2633.
- D. Edwards, S. Takahashi, M. S. Sherwin, S. Han, Distance measurements across randomly distributed nitroxide probes from the temperature dependence of the electron spin phase memory time at 240 GHz, J. Magn. Reson., 223 (2012) 198-206.
- T. Siaw, S. A. Walker, B. D. Armstrong, S. Han, Inductively coupled NMR probe for versatile dynamic nuclear polarization operation at 7 Tesla: observation of 61 ± 2% 1H polarization at 4 K, J. Magn. Reson., 221 (2012) 5-10.
- M. D. Lingwood, T. Siaw, N. Sailasuta, O. A. Abulseoud, H. R. Chan, B. D. Ross, P. Bhattacharya, S. Han, Hyperpolarized Water as an MRI Contrast Agent, Radiology, 265 (3) (2012).
- S. Takahashi, L.-C. Brunel, D. T. Edwards, J. van Tol, G. Ramian, S. Han, M. S. Sherwin, Pulsed electron paramagnetic resonance spectroscopy powered by a free-electron laser, Nature 489 (74160) (2012) 409-13.
- M. D. Lingwood, A. J. Sederman, M. D. Mantle, L. F. Gladden, S. Han, Overhauser dynamic nuclear polarization amplification of NMR flow imaging, J. Magn. Reson. 216 (2012) 94–100.
- C. Cheng, J. Wang, R. Kausik, K. C. Lee, S. Han, An ultrasensitive tool exploiting hydration dynamics to decipher weak lipid membrane–polymer interactions,J. Magn. Reson.215 (2012) 115-119.