A group computer facility/library, located across the hall from our labs, houses several Macintosh and PCs, as well as a Linux system used to run theoretical calculations and workup NMR spectra. We subscribe to most journals on organic chemistry, and we can carry out literature searches electronically with both Scifinder and Reaxys. Microsoft Office as well as programs such as ChemDraw are available at each station.
Our group has a Perkin Elmer Model 341 Polarimeter. This instrument is useful for determining the optical rotation of optically active compounds. It features both Na (589 nm) and Hg lamps and is primarily used for measuring the specific rotation of compounds in solution held in a quartz cell that was specifically designed for this type of polarimeter.
Group members have access to two HP/Agilent gas chromatographs. Controllable through Agilent's ChemStation™ interface, the instruments can be equipped with a wide variety of capillary columns to separate compounds both achiral and chiral in nature. The group is also equipped with a new Agilent 7890A GC with a 16 sample tray for automated injections.
We recently installed the latest Agilent 7890 GC equipped with a 5975 MS detector. This system allows analyses of compounds up to 1050 AMU thanks to a gold/quartz quadrupole and has enhanced abilities to analyze samples from complex matrices. Included is an 8 vial auto-injector for unattended use of this instrument. Also, an EZ-swap fixture allows rapid changeover from different GC/MS columns with almost no downtime. All is controlled by the latest version of the MSD Productivity Chemstation© software.
We have two gloveboxes for one made by Vacuum Atmospheres and one made by Vigor. Both are equipped with an anti-static device to ensure easy weighing of water sensitize powdered reagents (e.g., LAH). As well they can be entered by either a small or large anti-chamber.
We have removed the stills and solely run our dry reactions with solvent from a PureSolv filtration system by Innovative Technology Inc..
High Performance Liquid Chromatography
Our group has a Shimadzu HPLC with a diode array detector spanning the UV/Vis range of frequencies. The quaternary pump with internal degasser facilitates complex gradient elution of both normal and reverse phase solvent systems. The system is equipped with a selection of columns, including columns with chiral packing for the separation of enantiomers. The operating software from Shimadzu runs on a standard Windows PC.
We have recently acquired a Perkin Elmer Spectrum Two UATR FT-IR Spectrometer. The diamond ATR requires a minimal amount of sample in its native state - solid or liquid, and thus does away with KBr pellets or oil mulls, though solutions can also be used. The machine is robust yet portable and can be placed in a hood or a glove-box if required. The software is very user-friendly and comes with spectral libraries against which the generated spectra can be compared.
No one likes to column, but often it has to be done. For those tricky columns that just never seem to give pure material, we have two automated flash column chromatography machines ready for use.