The Han lab's research pushes the frontiers of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy for the study of materials, macromolecular complexes and biological interactions. The particular emphasis is on the interrogation of interfaces and local structures through locally amplified NMR spectroscopy of materials and biological systems. The study of local features at the nanometer and sub nanometer scale is achieved through the use of strategic or intrinsic electron spin probes and by employing orders of magnitudes of signal enhancements, achieved through polarization transfer from the electron spin probes to the surrounding nuclear spins, which process is termed dynamic nuclear polarization (DNP).
Our approach is to take advantage of the existing power and plethora of state of the art magnetic resonance tools, in particular the detailed structure elucidating capabilities of modern NMR spectroscopy, as well as cw and pulsed EPR spectroscopy at low and high magnetic fields for measuring long range distances (2-8 nm) and macromolecular interactions. My group has been pursuing a broad research agenda, beginning from the development of unique instrumentation and new experimental methods, to the development of new applications for elucidating materials microstructure and biological interfaces.
The following is a list of our current areas of research. More information about a project can be found in the detailed categories or in recent publications.