Research

Magnetic Resonance Choreography of Spins
to Uncover Design Rules for Molecular Interactions and Surfaces

The Han lab performs advanced magnetic resonance choreography of electron and nuclear spins, located on biomolecular and materials surfaces, to uncover design rules for protein and polymer surfaces, protein assembly, protein function and activation, and the surface structuring of hydration water.

The Han Lab's research pushes the frontiers of magnetic resonance spectroscopy for the study of biomolecular interactions, biomolecular and materials surfaces, and the property of their hydration layers. The particular emphasis is on the interrogation of interfaces and local structures through locally amplified NMR spectroscopy of materials and biological systems. The study of local features at the nanometer and sub-nanometer scale is achieved through the use of strategic or intrinsic electron spin probes, and by employing orders of magnitudes of signal enhancements, achieved through polarization transfer from the electron spin probes to the surrounding nuclear spins, which process is termed dynamic nuclear polarization (DNP).

Our approach is to take advantage of the existing power and plethora of state of the art magnetic resonance tools, in particular the detailed structure elucidating capabilities of modern NMR spectroscopy, as well as continuous wave (cw) and pulsed EPR spectroscopy at low and high magnetic fields for measuring long range distances (2-8 nm) and macromolecular interactions. My group has been pursuing a broad research agenda, beginning from the development of unique instrumentation and new experimental methods, to the development of new applications for elucidating materials microstructure and biological interfaces.

The research topics currently pursued by the Han lab are listed:

 

More information about some of these research topics can be found in the detailed description below.