Present: Associate Professor, Materials Science and Engineering Department, İzmir Institute of Technology, Turkey.
Present: Senior Online Content Developer, The MathWorks.
Ryan's research focuses on the interface between proteins and the surrounding hydration water in order to better understand how hydration water modifies the protein function. By quantifying the motion of the protein as well as the motion of the water, he aims to address the energetic coupling between a protein and its solvating hydration water.
- (805) 893-2792
- PSBN 4623D
Present: Research Associate, Gritstone Oncology
Present: Senior Research Scientist, Colgate-Palmolive
Jessica's research in the Han Lab focused on high field electron paramagnetic resonance for the study of biological systems. This research helped build a better understanding of the processes that are important for the systems of spins at high field, aiming to develop new methods for styding biological systems. Jessica was developing a new tool for measuring distances in membrane proteins that will enhance their study of protein structure and dynamics. Under Mark Sherwin's guidance, she also helped develop the UCSB electron free laser as a tool for high field EPR.
Present: Design Verification Test Engineer III, Karl Storz Imaging
Present: Postdoctoral Researcher, University of Colorado, Boulder (Advisor: Prof. Thomas Perkins)
Neil focused on tau protein which aggregates to form long fibers inside neurons in the brain. He worked on understanding the early structural mechanism of the tau aggregation pathway. Tau aggregation is known to be associated with several neurodegenerative diseases known as Tauopathies which also include Alzheimer’s disease. By using double electron electron resonance (DEER), Neil was able to look at conformational changes both before and after inducing aggregation. Through tracking and characterizing specific conformational intermediates, it could be possible to locate structurally distinct targets for the treatment of tau related diseases.
Present: Project Manager, Infineon Technologies, Germany.
Present: Assistant Professor, Chemistry Department, Syracuse University
Present: Postdoctoral Researcher, National Institutes of Health
Ilia's main project involves technique development for high field EPR and DNP (at 7T). Presently, Ilia and his team are developing new approaches for more efficient DNP using unique capabilities of their spectrometer capable of generating arbitrary shaped pulses at 200 GHz.
The second project Ilia works on is part of large multidisciplinary collaboration dedicated to development of underwater adhesives based on mimicking the adhesives used by mussels in the ocean. They employ a range of techniques such as confocal microscopy, microrheology, EPR and Overhauser DNP to characterize the material and molecular properties of recently discovered adhesive coacervate phases.
- (805) 893-2792
- PSBN 4623D
Present: Founder and CEO of OTOjOY LLC
Present: Senior Research Scientist, Schlumberger-Doll Research
Present: Graduate Student Researcher, NSF Fellow, Stanford University (Advisor: Prof. Rajat Rohatgi)
Alisa’s research focuses on the interface of EPR, NMR, and dynamic nuclear polarization (DNP). She is working on hardware development for static DNP at high magnetic fields as well as doing mechanistic studies to better understand how static DNP is influenced by the electron environment and experimental conditions. These findings can then be used to optimize nuclear signals for materials and biological studies.
- (805) 893-2792
- PSBN 4623C
Present: Assistant Professor, St. Mary's College of California
Alicia’s research focuses on instrument design and pushing the technique of NMR, DNP and EPR, with a specific focus designing an MAS-NMR probe that has DNP and EPR capabilities at temperatures below 90 K. Encompassed in this probe design research are fundamental studies on quantifying absolute enhancement factors from various nitroxide radicals and how the electron spin dynamics affect the DNP mechanism, particularly under magic angle spinning NMR. This work also involves applications to heterogeneous catalytic materials, where surface enhanced NMR through DNP can help differentiate the surface species from the bulk of a material.
Present: Postdoctoral Researcher, Centre de Résonance Magnétique Nucléaire (CMRN), Lyon, France (Advisor: Prof. Anne Lesage)
Present: Principal Scientist, Korimako Chemical Limited, New Zealand
Present: Research Associate - Formulation Development, Regeneron Pharmaceuticals, Inc.
Present: Assistant Professor, Massachusett Institute of Technology
Present: Senior Scientist, Abzena
- Past Member (Postdoctoral Researcher)
Present: Foreign Affairs Officer and AAAS Science and Technology Policy Fellow, U.S. Department of State
Nikki was coadvised by Prof. Michelle O'Malley (ChE) and Prof. Songi Han (DCB). She worked on characterizing pharmaceutically relevant membrane protein complexes to link changes in structure and dynamics to function. Namely, she worked with a G protein-coupled receptor called the adenosine A2a receptor to elucidate structural details and functional consequences of homo-dimerization. The A2a receptor regulates cardiac function and several processes within the central nervous system; the outcome of this research will facilitate improved rational drug design to target A2a receptor oligomers in the treatment of disorders such as inflammation, fibrosis, schizophrenia and Parkinson's disease.
Alex's research focuses on hydration on a molecular level. The question he is most concerned with is how and why are hydrophilic surfaces hydrated in both biological systems as well as non-biological or inorganic systems? He is working on solving this mystery by performing DNP measurements and surface force measurements. Apart from this, he works on the correlattion of measurements of water diffusivity with surface forces specifically for hydrated hydrophilic surfaces.
Present: Instructor, Elite Educational Institute
Present: NMR R&D Scientist, JEOL USA
Present: Associate Director, R&D, Pacira Pharmaceuticals, Inc.
Till worked on a project on hardware design to run ODNP on fuel cells. He and Prof. Songi Han were attempting to analyze conduction pathways in polyelectrolyte membranes with the help of ODNP. They hoped to better understand the difference between the surface (backbone) diffusion and the bulk diffusion using the ODNP. By changing those diffusion behaviors and understanding how membrane diffusion works, they built up the base to obtain a higher efficiency for diffusion through the membrane.