Shona is coadvised by Prof. Bradley Chmelka (ChE) and Prof. Songi Han (DCB). She is investigating the synthesis and optimization of non-precious metal heteroatom-containing porous carbon materials. These conductive graphitic materials have proven to be both comparable to industrially employed oxygen reduction reaction catalyzing material in fuel cells, and promising grey water filtration materials. Additionally, she is investigating the structuring of conductive polymers for use in solar panel like applications.
- (480) 734-7610
- Engineering 2 3313
Chung-Ta focuses on how different environmental factors affect transmembrante protein function. He is working on the development of a distance measuring tool between protein helices that will allow him and his team to study how protein functions are modulated through the approach of protein structure dynamics.
Tim's aim is to use recently developed arbitrarily waveform generators to improve the current pulsed EPR experiments such as DEER, DQC, and SIFTER. He also aims to make potentially more effective experiments possible. The primary application of his work is to look at distances across proteins particularly for aggregating systems. He is trying to improve the study of distances on aggregating systems, especially on the model system of tau protein.
- (805) 893-2792
- PSBN 4614
Alisa’s research focuses on the interface of EPR, NMR, and dynamic nuclear polarization (DNP). She is working on hardware development for static DNP at high magnetic fields as well as doing mechanistic studies to better understand how static DNP is influenced by the electron environment and experimental conditions. These findings can then be used to optimize nuclear signals for materials and biological studies.
- (805) 893-2792
- PSBN 4623C
Miranda’s research so far is to improve Dynamic Nuclear Polarization (DNP) as a technique in terms of signal enhancement for biological materials. She has worked on biocompatible radicals to optimize Cross Effect DNP and have been looking at the solvent-radical interface in mixed radicals. She has now started working on bio NMR and learning the state-of-art ssNMR experiments like Cross-polarization, DARR, HNC, and REDOR.
- PSBN 4623B
Yanxian currently focuses on the complex coacervation of intrinsically disordered protein (IDP) and RNA. He applies three different methods to his research including magnetic resonance-based techniques to probe conformation and dynamics of IDP and RNA, polymer and colloid characterization approaches on the properties of complex coacervate, and bioinformatic approaches on predicting complex coacervation.
Kendrick is coadvised by Prof. Michelle O'Malley (ChE) and Prof. Songi Han (DCB). His project gives him a strong background in molecular cloning for site-directed mutagenesis, protein expression using E. coli and S. cerevisiae, membrane protein purification with the use of detergent micelles and relevant chromatography techniques (IMAC, affinity, and size exclusion), biophysical techniques such as EPR (including quantitative EPR and power saturation) and DEER, as well as basic knowledge into computational techniques such as MATLAB, PyMOL, Mathematica, etc. for data processing. He also has strong interests in medicine, drug discovery, pharmacology, and neurology.
Alex's research focuses on hydration on a molecular level. The question he is most concerned with is how and why are hydrophilic surfaces hydrated in both biological systems as well as non-biological or inorganic systems? He is working on solving this mystery by performing DNP measurements and surface force measurements. Apart from this, he works on the correlattion of measurements of water diffusivity with surface forces specifically for hydrated hydrophilic surfaces.
Tarnuma is coadvised by Prof. Susannah Scott (ChE) and Prof. Songi Han (DCB). She works on synthesis and characterization of heterogeneous catalytic systems using EPR techniques. Using a highly sensitive technique like EPR may allow better understanding of some of the more elusive mechanisms involved in these systems. This information can be applied to improve factors such as catalytic activity, efficiency, and selectivity. She is currently focusing on understanding supported vanadium- and rhenium-based systems which are widely used in olefin metathesis/polymerization reactions.
- PSBN 4623
- Graduate Student Researcher
- Graduate Student Researcher
Blake is coadvised by Prof. Mark Sherwin (Physics) and Prof. Songi Han (DCB). His focus is to work on developing high field EPR methods and performing high field EPR on systems to learn about the behavior of materials in a high field. By doing this, he helps build a better understanding of the processes that are important for the systems of spins at high field, aiming to develop new methods for studying biological systems. Under Mark Sherwin's guidance, Blake has also helped develop the UCSB electron-free laser as a tool for high field EPR.
Kate focuses on understanding the aggregation of tau, an intrinsically disordered protein (IDP) implicated in neurodegenerative diseases including Alzheimer`s Disease. She is interested in how tau can form extraordinarily stable amyloid fibrils, and aim to understand its aggregation behavior and seeding from a structural point of view. Currently, she is working on (1) seeding tau monomer with tau amyloid fibrils and (2) investigating the amyloid structure and fibril stability. She utilizes a number of biophysical techniques in her projects including ThT fluorescence, EPR, and DEER. With the background of polymer materials and engineering, she can provide new insights into biochemical and biophysical problems.
- PSBN 4653