Shona is coadvised by Prof. Bradley Chmelka (ChE) and Prof. Songi Han (DCB). She is investigating the synthesis and optimization of non-precious metal heteroatom-containing porous carbon materials. These conductive graphitic materials have proven to be both comparable to industrially employed oxygen reduction reaction catalyzing material in fuel cells, and promising grey water filtration materials. Additionally, she is investigating the structuring of conductive polymers for use in solar panel like applications.
- (480) 734-7610
- Engineering 2 3313
Chung-Ta focuses on how different environmental factors affect transmembrante protein function. He is working on the development of a distance measuring tool between protein helices that will allow him and his team to study how protein functions are modulated through the approach of protein structure dynamics.
Miranda’s research so far is to improve Dynamic Nuclear Polarization (DNP) as a technique in terms of signal enhancement for biological materials. She has worked on biocompatible radicals to optimize Cross Effect DNP and have been looking at the solvent-radical interface in mixed radicals. She has now started working on bio NMR and learning the state-of-art ssNMR experiments like Cross-polarization, DARR, HNC, and REDOR.
- PSBN 4623B
Yanxian currently focuses on the complex coacervation of intrinsically disordered protein (IDP) and RNA. He applies three different methods to his research including magnetic resonance-based techniques to probe conformation and dynamics of IDP and RNA, polymer and colloid characterization approaches on the properties of complex coacervate, and bioinformatic approaches on predicting complex coacervation.
Kendrick is coadvised by Prof. Michelle O'Malley (ChE) and Prof. Songi Han (DCB). His project gives him a strong background in molecular cloning for site-directed mutagenesis, protein expression using E. coli and S. cerevisiae, membrane protein purification with the use of detergent micelles and relevant chromatography techniques (IMAC, affinity, and size exclusion), biophysical techniques such as EPR (including quantitative EPR and power saturation) and DEER, as well as basic knowledge into computational techniques such as MATLAB, PyMOL, Mathematica, etc. for data processing. He also has strong interests in medicine, drug discovery, pharmacology, and neurology.
Tarnuma's research focuses on the characterization of supported catalytic materials under the direction of Prof. Susannah Scott and Prof. Songi Han. Her interests lie in using advanced magnetic resonance techniques, including both EPR and NMR, to investigate the structural driving forces and underlying mechanisms that dictate kinetic effects in reactions.
- PSBN 4623
Blake is coadvised by Prof. Mark Sherwin (Physics) and Prof. Songi Han (DCB). His focus is to work on developing high field EPR methods and performing high field EPR on systems to learn about the behavior of materials in a high field. By doing this, he helps build a better understanding of the processes that are important for the systems of spins at high field, aiming to develop new methods for studying biological systems. Under Mark Sherwin's guidance, Blake has also helped develop the UCSB electron-free laser as a tool for high field EPR.
Kate focuses on understanding the aggregation of tau, an intrinsically disordered protein (IDP) implicated in neurodegenerative diseases including Alzheimer`s Disease. She is interested in how tau can form extraordinarily stable amyloid fibrils, and aim to understand its aggregation behavior and seeding from a structural point of view. Currently, she is working on (1) seeding tau monomer with tau amyloid fibrils and (2) investigating the amyloid structure and fibril stability. She utilizes a number of biophysical techniques in her projects including ThT fluorescence, EPR, and DEER. With the background of polymer materials and engineering, she can provide new insights into biochemical and biophysical problems.
- PSBN 4653
Asif's main focus is method development and application of solid-state dynamic nuclear polarization (DNP) enhanced NMR to study biosolids, in particular aggregation intermediates of Tau proteins. In addition to this, understanding electron spin dynamics under non-continuous microwave irradiation condition is another major goal in the pursuit of improving DNP efficiency in power limited and faster magic-angle spinning frequency regime.
- PSBN 4623B
Yann's research focuses on protein aggregation which is involved in many diseases, such as Alzheimer's Disease, Parkinson's Disease, and others. His aim is to understand why proteins aggregate and to explain how the complex process of aggregation takes place. Yann is particularly interested in the earliest stages of aggregation.
- PSBN 4653
Sheetal's research focuses on the methods, development, and applications of DNP and NMR. His doctoral focus was in solid-state NMR, and now he has been working with pulsed DNP methods to improve the technique he used during his doctoral program. Presently, he is involved primarily in projects related to the instumentation and applications of DNP and NMR.
- PSBN 4623B
Tim's aim is to use recently developed arbitrarily waveform generators to improve the current pulsed EPR experiments such as DEER, DQC, and SIFTER. He also aims to make potentially more effective experiments possible. The primary application of his work is to look at distances across proteins particularly for aggregating systems. He is trying to improve the study of distances on aggregating systems, especially on the model system of tau protein.
- (805) 893-2792
- PSBN 4614
My main research goal is to understandthe effect of surfactants and hydration on membrane protein functions. We are currently studying the membrane protein proteorhodopsin (PR) because it is easily characterized by its optical properties and is a good model protein for other membrane proteins. We are aiming to modulate PR by adjusting the external and internal surface hydration while in lipid vesicles using different surface active species.
- (626) 283-0587
- PSBN 4650A
Andrew is working on elucidating the pathway of the tau protein’s aggregation into fibers, the cause of neurodegenerative diseases known as Tauopathies, including Alzheimer's disease. He assists with DEER spectroscopy distance measurements, ThT fluorescence, and small peptide production using molecular biology. In addition, he is in charge of creating tau mutants via site-directed mutagenesis, expressing and purifying these mutants, and preparing them for magnetic resonance experiments. One of his interests lies in optimizing spin-labelling efficiency for doubly spin-labelled IDPs, which could cut the time of DEER experiments in half. In doing this, he models the kinetics for, and studies the effects of solvent conditions on, multiple chemical reactions.