Tau Protein Aggregation Publications

2018 Journal Articles

Cofactors are essential constituents of stable and seeding-active tau fibrils
Y. Fichou, Y. Lin, J. N. Rauch, M. Vigers, Z. Zeng, M. Srivastava, T. J. Keller, J. H. Freed, K. S. Kosik, S. Han. Proc. Nat. Acad. Sci., 115 (52) (2018), 13234-13239.
DOI: 10.1073/pnas.1810058115
Highlighted in the UC Santa Barbara Current:
http://www.news.ucsb.edu/2018/019293/three-player-game
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
Y. Lin, J. McCarty, J. N. Rauch, K. T. Delaney, K. S. Kosik, G. H. Fredrickson, J.-E. Shea, S. Han.  bioRxiv (2018).
DOI: 10.1101/424358
Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer’s disease filaments
Y. Fichou, M. Vigers, A. K. Goring, N. A. Eschmann, S. Han, Chem. Commun.54 (36) (2018), 4573-4576.
DOI: 10.1039/C8CC01355Aa

2017 Journal Articles

Conformation-based assay of tau protein aggregation
Y. Fichou, N.A. Eschmann, T.J. Keller, S. Han, Methods Cell Biol., 141 (2017) 89-112.
DOI:10.1016/bs.mcb.2017.06.008
RNA Stores Tau Reversibly in Complex Coacervates
X. Zhang, N.E. Eschmann, Y. Lin, H. Zhou, J. Rauch, I. Hernandez, E. Guzman, K.S. Kosik, S. Han, PLOS Biol., 15 (7(2017) e2002183.
DOI:10.1371/journal.pbio.2002183. PMID: 28683104. PMCID: PMC5500003
Also published in bioRxiv: 
DOI:10.1016/
Highlighted in:

http://www.news.ucsb.edu/2017/018072/biophysical-smoking-gun
Signature of an aggregation-prone conformation of tau
N.A. Eschmann, E.R. Georgieva, P. Ganguly, P.P. Borbat, M.D. Rappaport, Y. Akdogan, J.H. Freed, J.E. Shea, S. Han, Sci. Rep., 7 (20171-10 
DOI:10.1038/srep44739. PMID: 28303942 PMCID: PMC5356194.

2016 Journal Article

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau
A. Pavlova, C. Cheng, M. Kinnebrew, J. Lew, F. Dahlquist, S. Han, Proc. Natl. Acad. Sci., 113 (2) (2016) E127-E136
PMCID: PMC4720316
DOI:10.1073/pnas.1504415113 

2015 Journal Article

Tau Aggregation Propensity Engrained in Its Solution State
N. Eschmann, T. Do, N. LaPointe, J. Shea, S. Feinstein, M. Bowers, S. Han, J. Phys. Chem., 119 (45) (2015) 14421–14432
PMCID: PMC4645975
DOI: 10.1021/acs.jpcb.5b08092