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Plaxco, K.W. and Gross, M. Astrobiology; A Brief Introduction Johns Hopkins University Press. (2006) In press
66. Seferos, D.S., Lai, R.Y., Plaxco, K.W. and Bazan, G.C. (2006) “a,w-Dithiol oligo(phenylenevinylene)s for the preparation of high-quality conjugated SAMs and nanoparticle functionalized electrodes.” Adv. Funct. Mat., Submitted.
65. Lubin, A.A, Lai, R.Y., Baker, B.R., Heeger, A.J. and Plaxco, K.W. (2006) “On the sequence specificity, selectivity and reusability of E-DNA, a reagentless, electronic DNA sensor.” Anal. Chem., Submitted.
64. Xu, J., Plaxco, K.W. and Allen, S.J. (2006) “0.3 – 3.72 Terahertz absorption spectroscopy of a protein in liquid water.” Prot. Sci., Submitted.
63. Kohn, J.E., Gillespie, B. and Plaxco, K.W. (2006) “Non-sequence specific interactions can account for the compaction of unfolded proteins in the absence of denaturant.” J. Mol. Biol, Submitted.
62. Baker, B.R., Lai, R.Y., Wood, M.S., Doctor, E.H., Heeger, A.J. and Plaxco, K.W. (2006) “An electronic, aptamer-based small molecule sensor for the rapid, reagentless detection of cocaine in adulterated samples and biological fluids.” J. Am. Chem. Soc. Submitted
61. de los Rios, M.A., Muralidhara, B.K., Wildes, D., Marqusee, S., Wittung-Stafshed, P., Plaxco, K.W. and Ruczinski, I. (2005) “On the precision of experimentally determined folding rates and f-values.” Prot. Sci., In press.
60. Lai, R.Y, Lee, S-H., Soh, H., Plaxco, K.W. and Heeger, A.J. (2005) “Differential labeling of closely-spaced biosensor electrodes via electrochemical lithography.” Langmiur, In press.
59. Xu, J., Plaxco, K.W. and Allen, S.J. (2005) “Absorption spectra of liquid water and aqueous buffers between 0.3 - 3.72 terahertz.” J. Chem. Phys. In press.
58. Lai, R.Y., Lagally, E.T., Lee, S.-H., Soh, T.H., Plaxco, K.W. and Heeger, A.J. (2005) “Sequence-specific electronic detection of unpurified PCR amplicons via a reusable, electronic sensor.” Proc. Natl. Acad. Sci. USA, In press.
57. Xiao, Y., Piorek, B.D., Heeger, A.J. and Plaxco, K.W. (2005) “A reagentless, signal-on design for electronic aptamer-based sensors via target-induced strand displacement.” J. Am. Chem. Soc., 127, 17990-17991
56. de los Rios, M.A., Danashi, M. and Plaxco, K.W. (2005) “The frequency and substitution-dependence of negative f-values.” Biochemistry, Biochemistry, 44, 12160 -12167
55. McCarney, E.R., Werner, J.H., Ruczinski, I., Makarov, Goodwin, P.M. and Plaxco, K.W. (2005) “Random coil dimensions in a highly denatured protein; A single molecule study.” J. Mol. Biol., 352, 672-682
54. Kohn, J.E. and Plaxco, K.W. (2005) “Engineering of a signal-transduction mechanism for protein-based biosensors.” Proc. Natl. Acad. Sci. USA, 102, 10841-10845
53. Xiao, Y., Lubin, A.A., Heeger, A.J. and Plaxco, K.W. (2005) “Label-free electronic detection of thrombin in blood serum using an aptamer based electrochemical sensor.” Angw. Chem. Int. Ed., 44, 2-5
52. McCarney, E.R., Kohn, J.E.
and Plaxco, K.W. (2005) “Is there or isn’t
there? The case for (and against) residual structure in chemically denatured
proteins.” Crit. Rev. Bioch. Mol. Biol., 40, 181-189
51. Fan, C., Plaxco, K.W. and Heeger, A.J. (2005) “Ligand-modulated
electron- or energy-transfer as a biosensor signaling mechanism.” Trends
Biotech., 23,186-192
50. Maxwell, K.L., Wildes, D., Zarrine-Afsar, A., de los Rios, M.A., Brown, A.G., Friel, C.T, Hedberg, L., Horng, J-C., Bona, D., Miller, E.J., Vallée-Bélisle, A., Main, E.R.G., Bemporad, F., Qiu, L., Teilum, K., Vu, N.-D., Edwards, A.M., Ruczinski, I., Poulsen, F.M., Kragelund, B.B., Michnick, S.W., Chiti, F., Bai, Y., Hagen, S.J., Serrano, L., Oliveberg, M., Raleigh, D.P., Wittung-Stafshede, P., Radford, S.E., Jackson, S.E., Sosnick, T.R., Marqusee, S., Davidson, A.R., Plaxco, K.W. (2005) “Protein folding: defining a ‘standard’ set of experimental conditions and a preliminary kinetic data set of two-state proteins.” Prot. Sci., 14, 602-616.
49. de los Rios, M. A. and Plaxco, K.W. (2005) “Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein.” Biochemistry, 44, 1243-1250
48. Raleigh, D.S. and Plaxco, K.W. (2005) “Plasticity and heterogeneity in the folding nucleus; what are f-values really telling us?” Prot. Pep. Sci., 12, 117-122
47. Xu, J., Ramian, G.J., Galan, J.F., Savvidis, P.G., Scopatz, A.M., Birge, R.R., Allen, S.J. and Plaxco, K.W. (2004) “Terahertz circular dichroism spectroscopy of biomolecules.” In: Chemical and Biological Standoff Detection. J.O. Jensen and J-M. Theriault, Eds. Proceedings of the SPIE, Vol. 5268, pp 19-26
46. Gillespie, B. and Plaxco, K.W. (2004) “Can theory predict two-state protein folding rates? An experimental perspective.” In: Forces, Growth and Form in Soft Condensed Matter: At the Interface between Physics and Biology, Skjeltorp, A.T. and Velushkin, A.V., Eds, Kluwer Academic Publishers BV, Dordrecht, Netherlands, pp 93-111
45. Kohn, J.E., Millett, I.S., Jacob, J., Zagrovic, B., Dillon, T., Cingel, N., Seifert, S., Thiyagarajan, P., Sosnick. T.R., Ruczinski, I., Hasan, M.Z., Pande, V.S. Doniach, S. and Plaxco, K.W (2004) “Do the dimensions of chemically unfolded proteins differ significantly from the expectations of a random-coil model?” Proc. Natl. Acad. Sci. USA, 101, 12491-12496
44. Gillespie, B. and Plaxco, K.W. (2004) “Using protein folding rates to test protein folding theories.” Ann. Rev. Biochem. Biophys., 73, 837-859
43. Raleigh, D.S. and Plaxco, K.W. (2004) “Plasticity and heterogeneity in the folding nucleus; what are phi values really telling us?” Prot. Pep. Sci., In press
42. Gillespie, B. and Plaxco, K.W. (2003) “Can theory predict two-state protein folding rates? An experimental perspective.” Form, growth and structure in soft condensed matter: At the interface between physics and biology, A. Skjeltorp, Ed., Kluwer Academic Publishers BV, Dordrecht, Netherlands, In press
41. Xu, J., Ramian, G.J., Galan, J.F., Savvidis, P.G., Scopatz, A.M., Birge, R.R. Allen, S.J. and Plaxco, K.W. (2004) “Terahertz circular dichroism spectroscopy of biomolecules.” SPIE Proceedings SPIE Press, 3, 489-504
40. Xu, J., Ramian, G.J., Galan, J.F., Savvidis, P.G., Scopatz, A.M., Birge, R.R. Allen, S.J. and Plaxco, K.W. (2003) “Terahertz circular dichroism spectroscopy: a potential approach to unbiased, in situ life detection.” Astrobiology, 3, 489-504
39. Ivankov, D.N., Alm, E., Plaxco, K.W., Baker, D. and Finkelstein, A.V. (2003) “Contact order revisited: the influence of protein size on folding rates.” Prot. Sci., 12, 2057-2062
38. Fan, C., Plaxco, K.W. and Heeger, A.J. (2003) “Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.” Proc. Natl. Acad. Sci. USA, 100, 9134-9137
37. Gillespie, B., Vu, D., Shah, P.S., Marshall, S., Dyer, R.B., Mayo, S.L., and Plaxco, K.W. (2003) “NMR and Temperature Jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics.” J. Mol. Bio., 330, 813-819
36. Calloni, G., Taddei, N., Plaxco, K.W., Ramponi, G., Stefani, M. and Chiti, F. (2003) “Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding.” J. Mol. Bio., 330, 577-591.
35. Fan, C., Wang, S., Hong, J.M., Bazan, G.C., Plaxco, K.W. and Heeger, A.J. (2003) “Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.” Proc. Natl. Acad. Sci. USA, 100, 6297-6301
34. Fan, C., Hirasa, T., Plaxco, K.W. and Heeger, A.J. (2003) “Photoluminescence quenching of water-soluble conjugated polymers by viologen derivatives: effect of hydrophobicity.” Langmiur, 19, 3554-3556
33. Jewett, A., Pande, V.S. and Plaxco, K.W. (2003) “Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates.” J. Mol. Bio., 326, 247-253
32. Makarov, D.E. and Plaxco, K.W. (2003) “The topomer search model: a quantitative, first-principles description of two-state protein folding kinetics.“ Prot. Sci., 12, 17-26.
31. Fan, C., Gillespie, B., Wang, G., Heeger, A.J. and Plaxco, K.W. (2002) “Spectroscopy and electrochemistry of the pyridine-chytochrome c complex and the pyridine-induced ‘alkaline-like’ conformation.” J. Phys. Chem. B, 106, 11375-11383
30. Millett, I.S., Doniach, S. and Plaxco, K.W. (2002) “Towards a taxonomy of the denatured state: small angle scattering studies of unfolded proteins.” Adv. Prot. Chem., 62, 241-262
29. Thompson, J.B., Hansma,, H.H., Hansma, P.K. and Plaxco, K.W. (2002) “The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy.” J. Mol. Bio., 322, 645-652
28. Fan, C., Plaxco, K.W. and Heeger, A.J. (2002) "High-efficiency fluorescence quenching of conjugated polymers by proteins." J. Am. Chem. Soc., 124, 5642-5643
27. Millett, I.S., Doniach, S. and Plaxco, K.W. (2002) "Towards a taxonomy of the denatured state: small angle scattering studies of unfolded proteins." Adv. Prot. Chem., in press.
26. Larson, S., Ruczinski, I., Davidson, A.R., Baker, D. and Plaxco, K.W. (2002) "Protein folding nuclei exhibit little evidence of preferential conservation." J. Mol. Biol., 316, 225-233
25. Makarov, D.E., Keller, C.A., Plaxco, K.W. and Metiu, H. (2002) "How the folding rate constant of simple-single domain proteins depends on number of native contacts." Proc. Natl. Acad. Sci. USA, 99, 3535-3539
24. Millet, I.S., Townsley, L., Chiti, F., Doniach, S. and Plaxco, K.W. (2002) "Equilibrium collapse and the kinetic ‘foldability’ of proteins." Biochemistry, 41, 321-325
23. Plaxco, K.W. and Gross, M. (2001) "Unfolded, yes, but random? Never!" Nat. Struct. Biol., 8, 659-670
22. Gillespie, B. and Plaxco, K.W. (2000) "Non-glassy kinetics in the folding of a simple, single domain protein." Proc. Natl. Acad. Sci. USA, 97, 12014-12019
21. Plaxco, K.W., Simons, K.T., Ruczinski, I., and Baker, D. (2000) "Sequence, stability, topology and length; the determinants of two-state protein folding kinetics." Biochemistry, 39, 11177—11183
20. Plaxco, K.W., Larson, S., Ruczinski, I., Riddle, D.S., Thayer, E.C., Buchwitz, B., Davidson, A.R. and
19. Viani, M.B., Schaffer, T.E., Paloczi, G.T., Pietrasanta, L., Smith, B.L, Thompson, J.B., Reif, M., Gaub, H.E., Plaxco, K.W., Cleland, A., Hansma, H.G. and Hansma, P.K. (1999) "Fast imaging and fast force spectroscopy of single biopolymers with anew atomic force microscope designed for small cantilevers." Rev. Sci. Inst., 70, 4300-4303
18. Plaxco, K. W., Millett, I. S., Segel, D. J., Doniach, S. and Baker, D. (1999) "Polypeptide chain collapse can occur concomitantly with the rate limiting step in protein folding." Nat. Struct. Biol., 6, 554-557
17. Plaxco, K. W. and Dobson, C. M. (1998) "Monitoring protein folding using time-resolved biophysical techniques." in Protein Dynamics, Function and Design, O. Jardetzky and J. Lefevre, eds., Plenum Press, New York, pp 331-332
16. Plaxco, K. W. and Baker, D. (1998) "Limited internal friction in the rate limiting conformational change of a two-state protein folding reaction." Proc. Natl. Acad. Sci. USA, 95, 13591-13596
15. Plaxco, K. W. (1998) "Protein chemistry comes of age. Again." Trends in Biotech., 16, 278
14. Plaxco, K. W., Simons, K. T. and Baker, D. (1998) "Contact order, transition state placement and the refolding rates of single domain proteins." J. Mol. Biol., 277, 985-994
13. Plaxco, K. W., Riddle, D. S., Grantcharova, V. and Baker, D. (1998) "Simplified proteins: Minimalist solutions of the ‘protein folding problem’." Curr. Op. Struct. Biol, 8, 80-85
12. Guijarro, J. I., Morton, C. J., Plaxco, K. W., Campbell, I. D. and Dobson, C. M. (1998) "Folding kinetics of the SH3 domain of PI3 by real-time NMR and optical techniques." J. Mol. Biol., 275, 657-667
11. Plaxco, K. W., Guijarro, J. I., Morton, C. J., Pitkeathly, M., Campbell, I. D. and Dobson, C. M. (1998) "The folding kinetics and thermodynamics of the FynSH3 domain." Biochemistry, 37, 2529-2537
10. O'Brien, R., Wynn, R., Driscoll, P. C., Davis, B., Plaxco, K. W.,. Sturtevant, J. M. and Ladbury, J. E. (1997) "The adaptability of Escherichia coli thioredoxin to non-conservative amino acid substitutions." Prot. Sci., 6, 1325-1332
9. Gross, M. and Plaxco, K. W. (1997) "Protein engineering: reading, writing and re-designing." Nature, 367, 419-420
8. Plaxco, K. W., Morton, C. J., Grimshaw, S., Jones, J. A., Pitkeathly, M., Campbell, I. D. and Dobson, C. M. (1997) "The effects of guanidine hydrochloride on the ‘random coil’ conformations and NMR chemical shifts of the peptide series GGXGG." J. Biomolec. NMR, 10, 221-230
7. Plaxco K. W. and Gross, M. (1997) "The importance of being unfolded." Nature, 386, 657-659
6. Plaxco, K. W., Spitzfaden, C., Campbell, I. D. and Dobson, C. M. (1997) "Comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules." J. Mol. Biol. 270, 763-770
5. Plaxco, K. W. and Dobson, C. M. (1996) "Time-resolved biophysical methods in the study of protein folding." Curr. Opin. Struc. Biol., 6, 630-636
4. Plaxco, K. W., Spitzfaden, C., Campbell, I. D. and Dobson, C. M. (1996) "Rapid folding of a proline rich, all beta-sheet fibronectin type III domain." Proc. Natl. Acad. Sci. USA, 93, 10703-10706
3. Plaxco, K.W. and Goddard, W.A. III (1994) "Contributions of the thymine methyl group to the specific recognition of poly- and mono-nucleotides: An analysis of the relative free energy of solvation of thymine and uracil." Biochemistry 33, 3050-3054
2. Plaxco, K. W., Mathiowetz, A. A., and Goddard, W. A. (1989) "Predictions of structural elements for the binding of hin recombinase with the hix site of DNA". Proc. Nat. Acad. Sci. U.S.A., 86, 9841-9845
1. Mason, F. R., Leong, F-C.,Plaxco, K. W. and Morton, T. H. (1985) "Two step covalent modification of proteins: Selective labeling of schiff base forming sites and selective blockade of the sense of smell in vivo." J. Am. Chem. Soc., 107, 6075-6084