In the Han Lab, we are developing novel magnetic resonance concepts and techniques that enables one to detect and monitor smaller quantities, larger molecules and faster processes than conventionally feasible. The underlying principle is to utilize high electron spin polarization of various nitroxide spin labels to enhance the nuclear magnetic resonance (NMR) signal of sensor atoms and molecules; this principle is known as dynamic nuclear polarization (DNP). We combine novel DNP approaches, CW and pulsed electron spin resonance (ESR) at 10, 200 and 240 GHz as well as NMR techniques to exploit complex biological phenomena, such as protein aggregation and folding, lipid membrane dynamics and the supramolecular structure and function of membrane-embedded proteins. We have strong expertise in NMR spectroscopy and imaging, and we are also interested in visualizing and monitoring chemical and biological processes. Find out more in the research section.

Group Picture Spring 2008

Department of Chemistry and Biochemistry
University of California
Santa Barbara, CA 93106-9510
Labs: Chem 3201, 3215
Offices: Chem 3219, 3223