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Long-range
membrane processes |
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| A cell membrane is
in constant motion. The undulating fluid bilayer, aside from its
unique role in cell compartmentalization, is home to an assortment
of biological molecules. Many of these molecules, such
as channels and transport proteins, add another layer of sophistication to simple filtering mechanisms
of the bilayer. Other trans-membrane proteins transmit signals
across the membrane, while carbohydrates attached to the cytosolic
side of the bilayer aid in cell-cell recognition. Such cellular
processes all depend on the behavior of the membrane.
We are currently developing algorithms to study the role of membrane
fluctuations in various biological processes on mesoscopic
and macroscopic time scales. |
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Solvent-free particle based model |
Continuous model using Fourier space Brownian dynamics |
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Single Molecule
Spectroscopy |
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The advent of single molecule spectroscopic techniques
has led to the experimental study of condensed phase systems with previously
unimaginable precision. We are developing theoretical and computational
tools for the interpretation of single molecule experiments. more...
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